FIG. 2.
Mice lacking functional receptors for both IFN-α/β and IFN-λ exhibit high susceptibility toward influenza virus strain B/Lee/40. (A) Survival of IFNAR10/0 mice (filled symbols; 5 × 102 PFU [n = 7] and 5 × 104 PFU [n = 10]) and IFNAR10/0IL28Rα0/0 double-knockout mice (open squares; n = 4) after intranasal infection with the indicated doses of virus. Combined data for two independent experiments are shown. (B) Virus titers in lungs at 72 h following intranasal infection with 5 × 104 FFU of virus. Combined data for several independent experiments are shown. Each dot represents the data for one animal. *, P < 0.05; **, P < 0.01; ***, P < 0.001.