FIG. 8.
IFN-λ contributes to restriction of SARS-CoV replication in both lungs and intestinal tracts of mice. (A) Virus titers in lungs of various mouse lines at day 4 following intranasal infection with 106 PFU of SARS-CoV per animal. Combined data for two independent experiments are shown. Each dot represents the data for one animal. *, P < 0.05; ***, P < 0.001. (B) At days 4 and 14 postinfection, RNA samples extracted from 20 droppings of cages harboring the different mouse lines were analyzed by qRT-PCR for SARS-CoV. (C) RNA samples from intestines of infected wild-type and IFNAR10/0IL28Rα0/0 double-knockout mice were analyzed by qRT-PCR for SARS-CoV. Viral RNA levels were calculated using appropriate standards.