FIG. 3.

(A) Representative results from three high Gag responders and four low Gag responders, showing inhibition of viral replication over 7 days of culture. Open squares represent CD4 T cells infected with NL4-3; closed circles represent CD4/CD8 cocultures; open circles represent CD4 T cells without superinfection with NL4-3. (B) Capacity of CD8 T cells from high Gag responders (n = 13) versus low Gag responders (n = 13) to inhibit replication of HIV-1 wild-type virus in autologous CD4 T cells. Log₁₀ p24 antigen concentration was measured in supernatants taken from cocultures of CD4 T cells infected with a reference strain of HIV-1 (NL4-3) to which autologous isolated CD8 T cells were added. Values shown are from day 5 or 7, depending on which day showed peak differences in p24 inhibition. Lines represent mean values ± standard deviation (SD).