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. 2010 Mar 24;84(11):5540–5549. doi: 10.1128/JVI.02031-09

FIG. 4.

FIG. 4.

(A) Ability of HIV-specific CD8 T cells from high Gag responders (n = 11) versus low Gag responders (n = 11) to secrete IFN-γ and IL-2 and to degranulate upon stimulation with HIV peptide pools. Monofunctional cells typically included CD8 T cells that degranulated (upregulated CD107a expression), and double-positive cells included those that degranulated and secreted IFN-γ, while the triple-positive cells also were primed to secrete IL-2. (B) Representative results from a high Gag and a low Gag responder showing CD107a expression and IFN-γ secretion after stimulation with HIV peptide pools (Gag, Pol, and Env). The high Gag responder exhibits type 2 functional responses after stimulation with Gag and Pol, whereas the low Gag responder reacts just to the Env peptide pool with CD107a expression. (C) Correlation between inhibitory capacity and polyfunctionality of HIV-specific CD8 T cells. For type 3 functions, Spearman's r = 0.44 and P < 0.05; for type 2 functions, Spearman's r = 0.57 and P = 0.005; for type 1 function, Spearman's r = −0.59 and P < 0.004.