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The coiled-coil domain modulates recognition of MLV derivatives by human wild-type PRYSPRY. MDTF-derived cell lines expressing indicated TRIM5α chimeras were transduced in duplicate with a single dose of N-MLV (left panels), B-MLV (middle panels), and Mo-MLV (right panels) GFP vectors harboring either a wild-type (WT) or the indicated mutant capsid. Infectivity was scored 72 h later by flow cytometry. The data are representative of two independent experiments.
