TABLE 2.
Multiplicity of HIV-1 infection in IDU, heterosexual, and MSM subjects
| Cohort | Reference | Virus subtype | Total no. of subjects | Single-variant transmission |
Multiple-variant transmission |
P value | Odds ratio | 95% CI | Median | Range | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of subjects | % of total | No. of subjects | % of total | |||||||||
| Heterosexuals | Keele et al. (18) | B | 79 | 65 | 82.30 | 14 | 17.70 | 1 | 1-4 | |||
| Abrahams et al. (1) | C | 69 | 54 | 78.30 | 15 | 21.70 | 1 | 1-5 | ||||
| Haaland et al. (13) | A or C | 27 | 22 | 81.50 | 5 | 18.50 | 1 | 1-6 | ||||
| Total | 175 | 141 | 80.60 | 34 | 19.40 | 0.008a | 6.14 | 1.37-31.27 | 1 | 1-6 | ||
| MSM | Keele et al. (18) | B | 22 | 13 | 59.10 | 9 | 40.90 | 1 | 1-6 | |||
| Li et al. (24) | B | 28 | 18 | 64.30 | 10 | 35.70 | 1 | 1-10 | ||||
| Total | 50 | 31 | 62.00 | 19 | 38.00 | 0.294b | 2.41 | 0.50-13.20 | 1 | 1-10 | ||
| IDUs | Bar | B | 10 | 4 | 40.00 | 6 | 60.00 | 3 | 1-16 | |||
a
Fisher's exact test of multiple-variant transmission in heterosexuals versus in IDUs.
b
Fisher's exact test of multiple-variant transmission in MSM versus in IDUs.