FIG. 8.

Calculation of the probability of transmission of a single viral variant given the measured HCV population structures. The x axis shows the number of viruses modeled to be involved in functional HCV transmission. The y axis shows the probability of detecting only one type of viral particle in the recipient in the donor-recipient transmission pair. Each of the subjects studied here was modeled individually as a potential donor and is shown as a single curve. The E1E2 HVR1 amplicon was used for this analysis. For subjects for whom multiple time points were available, the last time point was analyzed. Probabilities were calculated as described in the text. The dashed line indicates a P value of 0.05.