TABLE 1.
Clinical and hematological parameters of tumor-bearing animals at 5 days, 30 days, and 1 year posttreatment
| Clinical and hematological parametera | 5 days |
1 month |
1 year |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Naïve |
Saline |
HC-Ad |
Naive |
HC-Ad |
Naive |
HC-Ad |
||||||||
| Median | Range | Median | Range | Median | Range | Median | Range | Median | Range | Median | Range | Median | Range | |
| AST (U/liter) | 109.0 | 93-233 | 131.5 | 83-260 | 113.0 | 90-227 | 231.0 | 79-333 | 78.5 | 47-227 | 67.0 | 62-77 | 78.0 | 58-93 |
| ALT (U/liter) | 47.0 | 42-82 | 46.5 | 31-57 | 34.0 | 31-46 | 68.5 | 38-80 | 29.0 | 23-46 | 40.0 | 37-52 | 36.5 | 30-47 |
| Total bilirubin (mg/dl) | 0.1 | 0.1-0.1 | 0.2 | 0.1-0.9 | 0.3 | 0.3-0.4 | 0.1 | 0-0.1 | 0.1 | 0.1-0.4 | 0.1 | 0.1-0.1 | 0.1 | 0.1-0.1 |
| AP (U/liter) | 338.0 | 279-349 | 162.5 | 102-369 | 246.0 | 198-319 | 332.5 | 305-362 | 248.0 | 129-333 | 213.0 | 191-268 | 183.5 | 144-229 |
| Protein | 5.7 | 5.4-5.8 | 6.2 | 5.6-6.8 | 6.2 | 6-6.4 | 6.0 | 5.6-6.3 | 5.8 | 5.4-6.4 | 6.2 | 5.9-6.3 | 6.1 | 5.7-6.5 |
| Albumin | 3.5 | 3.2-3.6 | 3.0 | 2.6-3.3 | 3.1 | 3.1-3.2 | 3.3 | 2.9-3.5 | 3.0 | 2.8-3.2 | 3.1 | 2.9-3.2 | 3.0 | 2.9-3.2 |
| Globulin | 2.2 | 2.2-2.2 | 3.2 | 2.7-3.5 | 3.1 | 2.9-3.2 | 2.7 | 2.6-2.8 | 2.8 | 2.6-3.2 | 3.1 | 2.9-3.2 | 3.1 | 2.8-3.3 |
| Cholesterol (mg/dl) | 78.0 | 78-83 | 94.0 | 70-155 | 88.5 | 86-103 | 110.5 | 76-119 | 77.0 | 68-103 | 100.5 | 93-104 | 100.0 | 81-115 |
| BUN (mg/dl) | 21.0 | 20-22 | 21.0 | 14-39 | 24.5 | 22-25 | 23.0 | 20-33 | 22.0 | 16-27 | 20.5 | 18-23 | 17.0 | 13-18 |
| Creatinine (mg/dl) | 0.5 | 0.3-0.5 | 0.5 | 0.3-0.9 | 0.5 | 0.4-0.5 | 0.5 | 0.4-0.7 | 0.4 | 0.3-0.7 | 0.3 | 0.3-0.4 | 0.3 | 0.3-0.5 |
| BUN/creatinine ratio | 42.0 | 66.7-44 | 47.3 | 23.3-68 | 50.0 | 44-60 | 52.0 | 38.3-57.5 | 54.5 | 34-66.7 | 60.0 | 52.5-73.3 | 47.5 | 34-60 |
| Phosporus (mg/dl) | 13.9 | 9.8-15.4 | 14.7 | 11.8-21.4 | 18.2 | 13.6-22.7 | 18.5 | 9.5-25 | 10.6 | 9.4-22.7 | 6.8 | 6-8 | 7.1 | 6.5-11.6 |
| Calcium (mg/dl) | 9.6 | 9.2-9.9 | 10.1 | 7.8-12 | 10.3 | 9.3-11.4 | 9.0 | 8.4-9.5 | 10.2 | 9.3-11.4 | 10.2 | 9.8-10.2 | 9.8 | 9.6-12 |
| Glucose (mg/dl) | 196.0 | 160-275 | 220.0 | 84-385 | 140.5 | 82-182 | 143.0 | 106-194 | 188.0 | 82-399 | 187.5 | 143-206 | 206.0 | 169-366 |
| Sodium (mmol/liter) | 146.0 | 144-147 | 142.5 | 135-152 | 144.0 | 143-147 | 135.0 | 131-142 | 142.0 | 140-147 | 140.5 | 140-143 | 140.5 | 138-143 |
| Potassium (mmol/liter) | 11.8 | 11.3-12.9 | 12.0 | 7.8-18.9 | 11.5 | 9.7-12.6 | 20.6 | 9-27.5 | 8.2 | 7.1-12.6 | 8.9 | 7.7-9.4 | 8.4 | 7.2-9.8 |
| Chloride (mmol/liter) | 104.0 | 102-105 | 99.0 | 92-105 | 101.0 | 98-102 | 101.0 | 96-102 | 101.5 | 97-103 | 103.0 | 100-103 | 101.5 | 98-103 |
| CPK | 407.0 | 373-2,606 | 607.5 | 25-4,143 | 620.0 | 326-11,391 | 8,407.5 | 524-13,263 | 306.5 | 79-11,391 | 175.0 | 149-858 | 252.0 | 75-328 |
| White blood cells (103/μl) | 6.8 | 6.3-7 | 6.1 | 4.5-8.9 | 4.6 | 4.1-5.5 | 4.8 | 3.8-6.6 | 5.7 | 4.1-7.1 | 3.8 | 2.7-4.5 | 4.2 | 3.1-4.9 |
| Red blood cells (106/μl) | 8.2 | 7.6-9 | 8.9 | 8.3-10.1 | 8.5 | 7.9-8.8 | 8.6 | 7.7-9.1 | 8.8 | 7.9-9.3 | 8.7 | 7.8-8.9 | 9.0 | 8.6-9.3 |
| HGB (g/dl) | 14.8 | 13.6-15.9 | 14.8 | 14-16.6 | 14.1 | 13.1-15.2 | 13.8 | 12.7-14.7 | 14.6 | 13.1-15.3 | 14.1 | 13.3-14.4 | 14.8 | 14-15.5 |
| Mean corpuscular vol (fl) | 62.0 | 60-62 | 53.0 | 50-60 | 53.0 | 52-57 | 52.5 | 51-55 | 53.0 | 52-57 | 51.5 | 51-54 | 52.0 | 50-54 |
| Mean corpuscular hemoglobin (pg) | 17.8 | 17.7-18 | 16.4 | 15.9-17.2 | 16.8 | 16.5-17.3 | 16.2 | 15.9-16.5 | 16.6 | 16.1-17.3 | 16.3 | 15.8-17.1 | 16.4 | 16.1-16.9 |
| Neutrophils (103/μl) | 31.0 | 28-31 | 18.0 | 8-33 | 15.5 | 13-18 | 18.0 | 16-30 | 17.0 | 10-21 | 16.5 | 14-22 | 25.0 | 18-32 |
| Absolute neutrophils | 1,960.0 | 1,953-2,108 | 977.0 | 480-2,848 | 754.0 | 585-782 | 936.0 | 646-1,500 | 888.5 | 580-1,420 | 629.0 | 378-880 | 948.0 | 720-1,568 |
| Lymphocytes (103/μl) | 66.0 | 65-69 | 79.0 | 63-89 | 81.5 | 80-84 | 79.0 | 66-82 | 80.0 | 76-88 | 81.5 | 75-83 | 71.5 | 65-79 |
| Absolute lymphocytes | 4,488.0 | 4,095-4,830 | 4,781.0 | 3,690-5,874 | 3,730.0 | 3,280-4,565 | 3,476.0 | 3,002-5,412 | 4,565.0 | 3,280-5,538 | 3,035.5 | 2,241-3,690 | 3,063.5 | 2,139-3,408 |
| Mononuclear cells/μl | 2.0 | 2-2 | 2.0 | 1-3 | 2.0 | 1-2 | 1.0 | 1-1 | 1.0 | 1-3 | 1.5 | 1-2 | 2.0 | 1-2 |
| Absolute monocytes | 136.0 | 126-140 | 119.0 | 46-204 | 91.0 | 41-110 | 48.0 | 38-66 | 68.5 | 41-141 | 64.0 | 38-106 | 78.0 | 43-98 |
| Eosinophils/μl | 1.0 | 1-1 | 1.0 | 0-3 | 0.0 | 0-1 | 1.0 | 1-2 | 1.0 | 0-2 | 1.0 | 1-1 | 0.0 | 0-1 |
| Absolute eosinophils | 68.0 | 63-70 | 56.0 | 0-183 | 0.0 | 0-41 | 62.0 | 42-100 | 56.5 | 0-112 | 37.5 | 27-45 | 0.0 | 0-48 |
| Basophils/μl | 0.0 | 0-1 | 0.0 | 0-1 | 1.0 | 0-1 | 1.0 | 1-1 | 0.0 | 0-1 | 0.0 | 0-0 | 1.0 | 1-1 |
| Absolute basophils | 0.0 | 0-63 | 0.0 | 0-64 | 45.5 | 0-55 | 44.0 | 38-50 | 0.0 | 0-59 | 0.0 | 0-0 | 41.5 | 31-49 |
| Platelet count (103/μl) | 706.0 | 672-783 | 776.0 | 589-1,016 | 631.5 | 571-763 | 695.0 | 601-725 | 711.0 | 571-842 | 525.5 | 516-582 | 558.5 | 492-709 |
a
BUN, blood urea nitrogen; CPK, creatine phosphokinase; HGB, hemoglobin.