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Top-down view of the structure of the FMDV 3D(G62SM296I)-RNA complex. The polymerase is blue, and the RNA is yellow. Loops α2-α3 and β9-α11, containing the S62 and I296 substitutions, respectively, are red and green with the substituted amino acids represented as balls and explicitly labeled. The right inset shows a close-up of the hydrogen bonding network connecting the G62 region, the polymerase N terminus, the β9-α11 loop, and the active site.
