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. 2010 Apr 14;84(12):6188–6199. doi: 10.1128/JVI.02420-09

FIG. 6.

FIG. 6.

Surface representation of the active site of the FMDV 3D polymerase. Loop β9-α11 and the regions containing Asp245 (site A), Asn307 (site B), and Asp338 (site C) are shown for the different structures. (A) 3D(wild type)-RNA-RTP with the polymerase residues represented in blue and the template nucleotide U4 and the RTP molecule in yellow and red, respectively. (B) 3D(wild type)-RNA-ATP/UTP with the polymerase residues shown in light green and the template and incoming nucleotides in yellow and red, respectively. (C) 3D(M96I)-RNA with the polymerase residues shown in cyan. The RTP molecule (thin sticks in red) is modeled into the cavity to illustrate the steric impediment between the side chain of Asp245 and the RTP sugar moiety. (D) Structural superimposition of loop β9-α11 and the active-site residues in the three different structures, 3D(wild type)-RNA-RTP (dark blue), 3D(wild type)-RNA-ATP/UTP (light green), and 3D(M96I)-RNA (cyan).