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ATDC inhibits p53's transcriptional activation function. pBP100-GL2 and pGL3-control reporter plasmids were transfected into U2OS cells, with either the pcDNA3.1HA vector or the plasmid expressing HA-ATDC. Luciferase activity was determined 24 h after transfection, and values were normalized by protein concentration. The results from the averages of three independent experiments ± the SD are shown. Western blots were performed on whole-cell extracts to assess protein expression.
