TABLE 2.
Histomorphometric indices in the distal femur metaphysis endocortex of control and osteocyte-specific β-catenin cKO mice
| Histomorphometric indexa | Mean ± SEM inb: |
|||
|---|---|---|---|---|
| Female mice |
Male mice |
|||
| Control | cKOc | Control | cKOc | |
| dLS/BS (%) | 72.4 ± 6.0 | 33.7 ± 6.4** | 78.1 ± 4.0 | 49.7 ± 5.2** |
| MS/BS (%) | 77.0 ± 5.2 | 43.3 ± 4.5** | 83.0 ± 3.0 | 60.2 ± 6.2* |
| MAR (μm/day) | 2.5 ± 0.1 | 3.5 ± 0.3* | 3.1 ± 0.2 | 4.6 ± 1.1 |
| Ob.S/BS (%) | 80.0 ± 2.1 | 67.2 ± 5.5 | 42.7 ± 2.4 | 52.9 ± 11.5 |
| OS/BS (%) | 73.9 ± 2.3 | 61.7 ± 5.4 | 46.1 ± 3.2 | 53.8 ± 10.8 |
| Oc.S/BS (%) | 2.4 ± 0.4 | 17.1 ± 1.5** | 2.6 ± 0.6 | 13.2 ± 1.7* |
| ES/BS (%) | 1.1 ± 0.4 | 42.6 ± 5.6** | 3.3 ± 0.6 | 26.0 ± 8.0** |
a
Abbreviations: BS, bone surface; dLS, double-labeled surface; ES, eroded surface; MAR, mineral apposition rate; MS, mineralizing surface; Ob.S, osteoblast surface; Oc.S, osteoclast surface; OS, osteoid surface.
b
There were 3 to 11 mice in each group.
c
Values for 2-month-old homozygous cKO mice that were significantly different from the value for control littermate mice of the same gender using unpaired Student's t tests are shown as follows: *, P < 0.05; **, P < 0.01.