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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: Anal Chem. 2009 Nov 15;81(22):9306–9313. doi: 10.1021/ac901638z

Figure 5.

Figure 5

Effect of pharmacological agents on evoked dopamine concentration. A) Concentration vs time profiles from individual VNCs show that peak dopamine concentration is reduced when larva are chronically fed NSD-1015 (6.6 μM), a synthesis inhibitor, or are incubated in reserpine (100 μM), a VMAT inhibitor that disrupts vesicular packaging. B) The concentration of dopamine elicited by the first stimulation is significantly less for NSD-1015 (** p < 0.01) and reserpine (*** p < 0.001) than in samples dissected in buffer, but more than control experiments where ChR2 was not expressed. * p < 0.05, ** p < 0.01, *** p < 0.001.