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. 2007 Dec;13(12):1871–1878. doi: 10.3201/eid1312.061323

Table 3. Serologic evidence for influenza infections during the 24 months of follow-up.

Period N >4-fold increase
Swine influenza (H1N1)
Swine influenza (H1N2)
Human influenza (H1N1)
n Reported ILI,* 
n (%) n Reported ILI,* 
n (%) n Reported ILI,* 
n (%)
Enrollment to 12-mo follow-up 658 26 3 (11.5) 17 7 (41.2) 10 1 (10)
12- to 24--mo follow-up 586 109 18 (16.5) 16 2 (12.5) 19 3 (15.8)
Enrollment to 24-mo follow-up 654 141 31 (22) 23 2 (8.7) 20 3 (15)
Any increase between pairs of serum samples† 726 180 38 (21.1) 37 9 (24.3) 32 4 (12.5)

*Percentage of the participants who demonstrated a ≥4-fold increase in titer who also self-reported an influenza-like illness (ILI) during follow–up.
†From enrollment to 12 mo, 12 to 24 mo, or enrollment to 24 mo, among participants who permitted serum sample collections at least 2 times during the study.