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. Author manuscript; available in PMC: 2010 Oct 16.
Published in final edited form as: Cell. 2010 Apr 16;141(2):280–289. doi: 10.1016/j.cell.2010.02.026

Figure 1. Mitochondrial defects in 7 week old MLC-Cre/dm muscle.

Figure 1

(A) Whole-mount gastrocnemius muscles. The double mutant muscle (right) is smaller and deeper red. (B) Quantification of mitochondrial area in muscle of the indicated genotypes. The area occupied by mitochondria was measured from at least 10 representative EM fields and normalized to the area occupied by mitochondria in wildtype muscle. Asterisks (P<0.0003, unpaired t-test) indicate significant changes. (C–J) Electron microscopy of tibialis anterior (TA) longitudinal sections. Labels: s, length of sarcomere; Z, Z-disc; m, mitochondria. (C, E, and I) Wildtype. (D, F, and J) Mfn double mutant. (G) Mfn1−/−, Mfn2+/−. (H) Mfn1+/−, Mfn2−/−. (I and J) Subsarcolemmal mitochondria. Scale bars: 0.5 μm in C–F, I and J; 1μm in G and H. See also Figure S1.