Table 2.
Variations in bone mineral density (BMD, mg/cm2) in rabbit lumbar spine with respect to baseline conditions and 6 and 10 weeks after intervention: OVX and/or methylprednisolone succinate (MP) administration
| Baseline | 6 weeks after surgery | 10 weeks after surgery | |||
|---|---|---|---|---|---|
| Groups | BMD | BMD | ΔBMD [%] | BMD | ΔBMD [%] |
| Sham control | 304 (39) | 294 (30) | –10 (9) [–3.4] | 307 (40) | 3 (6) [1.0] |
| OVX | 293 (31) | 274 (23) | –19 (17) [–6.5] | 268 (22) | –25 (24) [–8.5] |
| MP | 296 (37) | 267 (25) | –30 (23) [–9.9] | 231 (33) | –65 (58) [–22] a |
| OVX+MP | 297 (36) | 250 (23) | –46 (28) [–16] a | 189 (12) | –107 (26) [–36] b |
BMD values (mg/cm2) are mean (SD). ΔBMD means variations in BMD 6 or 10 weeks after intervention. Values in square brackets represent the percentage of change from baseline.
a p <0.05) and
b p <0.001 compared to sham control group.