Figure 1.

Examples of Purkinje cell ouput. (A) A simple spiking cell, consisting entirely of high frequency Na⁺ spikes. (B) Mostly Na⁺ spike bursts, separated by near-random pauses. (C) A trimodal state, consisting of a tonic segment of simple spikes (the upswing of each pattern), followed by a period of Ca²⁺ spike bursts (both Na⁺ and Ca²⁺ spikes), and ending in a quiescent period, in a highly cyclic pattern. (D) Bursts of Na⁺/Ca²⁺ spike bursts, separated by pauses. (E,F) Application of the Na⁺ channel blocker, TTX, removes the Na⁺ spikes, leaving either a quiescent recording (E), or bursts of Ca²⁺ spikes (F).