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. 2010 Apr 1;19(12):2487–2496. doi: 10.1093/hmg/ddq130

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Figure 3. — Association between Ser704Cys substitution and centrosomal PCM1 immunoreactive area in white matter glia of human superior temporal gyrus. (A) There was an overall effect of genotype (P = 0.04), with PCM1 centrosomal immunoreactive area being decreased in heterozygotes when compared with Ser704 homozygotes, with a similar trend between Ser704 homozygotes and Cys704 homozygotes. (B) Data in (A) parsed by diagnosis. No effect of diagnosis nor genotype by diagnosis interaction was detected. (C) Centrosomal PCM1 immunoreactive area was significantly lower in Cys704 carriers compared with Ser704 homozygotes. (D) Data in (C) parsed by diagnosis. No effect of diagnosis nor genotype by diagnosis interaction was detected. (E) Ser704Cys affected centrosomal PCM1 immunoreactive area in African Americans (P = 0.004), being decreased in heterozygotes compared with Ser704 homozygotes. (F) No influence of Ser704Cys upon PCM1 centrosomal immunoreactive area was detected in Caucasians.