Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mutation profile of KIT and PDGFRA in 80 GIST. a) mutation frequency per gene; b) mutation frequency per PDGFRA exon; c) mutation frequency per KIT exon. Two patients with primary mutations in KIT exon 11 acquired the same secondary mutation in KIT exon 13 after imatinib treatment. The two patients with KIT exon 17 mutation belong to a family with hereditary GIST, with the mutation being found also in the germline.
