Table 2.
TNF-α and CCR5Δ32 genotype and allele frequencies in HC, EU and HIV-1-infected for assessment of associations with the risk of HIV-1 infection.
| Genotype and allele frequencies | HC (n = 203) |
EU (n = 36) |
HIV-1-infected (n = 184) |
p value * |
|---|---|---|---|---|
| TNF-α-238 G>A | ||||
| GG | 147 (87.5%) | 29 (80.5%) | 161 (87.5%) | |
| GA | 20 (12%) | 6 (16.7%) | 22 (12%) | 0.7 |
| AA | 1 (0.5%) | 1 (2.8%) | 1 (0.5%) | |
| GA+AA | 21 (12.5%) | 7 (19.5%) | 23 (12.5%) | 0.5 |
| Variant allele A | 22 (6.5%) | 8 (11.1%) | 24 (6.5%) | 0.3 |
| TNF-α-308G>A | ||||
| GG | 122(70.9%) | 24 (67%) | 148 (80.4%) | |
| GA | 42(24.4%) | 12 (33%) | 31 (16.8%) | 0.05 |
| AA | 8 (4.7%) | 0 | 5 (2.8%) | |
| GA+AA | 50 (29.1%) | 12 (33%) | 36 (19.6%) | 0.05 |
| Variant allele A | 58 (16.9%) | 12 (16.7%) | 41 (11.1%) | 0.07 |
| TNF-α-863 C>A | ||||
| CC | 116 (69.9%) | 27 (75%) | 137 (74.4%) | |
| CA | 44 (26.5%) | 8 (22%) | 45 (24.5%) | 0.7 |
| AA | 6 (3.6%) | 1 (3%) | 2 (1.1%) | |
| CA+AA | 50 (30.1%) | 9 (25%) | 47 (25.5%) | 0.6 |
| Variant allele A | 56 (16.8%) | 10 (14%) | 49 (13.3%) | 0.4 |
| CCR5Δ32 | ||||
| wt/wt | 174 (87%) | 31 (86.1%) | 144 (78.3%) | |
| wt/Δ32 | 26 (13%) | 5 (13.9%) | 40 (21.7%) | 0.15 |
| Δ32/Δ32 | 0 | 0 | 0 | |
| Δ32 allele | 26 (6.5%) | 5 (6.9) | 40 (10.9%) | 0.2 |
• HC: healthy controls
• EU: individuals repeatedly exposed to HIV-1 but uninfected
• wt indicates wild-type allele; Δ32, 32 bp deletion
• Genotype and allele numbers do not match the HC studied because DNA for TNF-α and CCR5 genotyping was not available or could not be amplified in some people
* χ2 test or Fisher exact test when necessary. p value arises from the comparison between HC, EU and HIV-1-infected.