Table 3.

TNF-α and CCR5Δ32 genotype and allele frequencies in the different subsets of HIV-1-infected patients for assessment of associations with disease progression.

Genotype and allele frequencies	HIV-1 TP (n = 109)	HIV-1 LTNP (n = 75)	p value *	HIV-1 LNTP-DVL (n = 55)	HIV-1 LTNP-EC (n = 20)	p value **
TNF-α-238G>A
GG	97 (90%)	64 (85.3%)		50 (90.9%)	14 (70%)
GA	11 (10%)	11 (14.7%)	0.35	5 (9.1%)	6 (30%)	0.02
AA	1 (1%)	0		0	0
GA+AA	12 (11%)	11 (14.7%)	0.6	5 (9.1%)	6 (30%)	0.02
Variant allele A	13 (6%)	11 (7.3%)	0.7	5 (4.5%)	6 (15%)	0.03
TNF-α-308 G>A
GG	86 (78.9%)	62 (82.7%)		46 (83.6%)	16 (80%)
GA	20 (18.3%)	11 (14.7%)	0.7	8 (14.5%)	3 (15%)	0.7
AA	3 (2.8%)	2 (2.6%)		1 (1.9%)	1 (5%)
GA+AA	23 (21.1%)	13 (17.3%)	0.5	9 (16.4%)	4 (20%)	0.7
Variant allele A	26 (11.9%)	15 (10%)	0.6	10 (9.1%)	5 (12.5%)	0.7
TNF-α-863 C>A
CC	84 (77.1%)	53 (70.6%)		37 (67.3%)	16 (80%)
CA	25 (22.9%)	20 (26.6%)	0.2	17 (30.9%)	3 (15%)	0.3
AA	0	2 (2.8%)		1 (1.8%)	1 (5%)
CA+AA	25 (22.9%)	22 (29.3%)	0.4	18 (32.7%)	4 (20%)	0.3
Variant allele A	25 (11.5%)	24 (16%)	0.2	19 (17.3%)	5 (12.5%)	0.4
CCR5Δ32
wt/wt	88 (80.7%)	57 (76%)		39 (70.9%)	18 (90%)
wt/Δ32	21 (19.3%)	18 (24%)	0.4	16 (29.1%)	2 (10%)	0.1
Δ32/Δ32	0	0		0	0
Variant allele Δ32	21 (9.6%)	18 (12%)	0.5	16 (14.5%)	2 (5%)	0.1

• HIV-1 TP: HIV-1-infected typical progressors

• HIV-1 LTNP: HIV-1-infected long-term nonprogressors

• HIV-1 LTNP-DVL: HIV-1-infected long-term nonprogressors with detectable plasma viral load

• HIV-1 LTNP-EC: HIV-1-infected long-term nonprogressors with undetectable plasma viral load

• wt indicates wild-type allele; Δ32, 32 bp deletion

* χ2 test or Fisher exact test when necessary. p value arises from the comparison between HIV-1 TP and HIV-1 LTNP.

** χ2 test or Fisher exact test when necessary. p value arises from the comparison between HIV-1 LTNP-DVL and HIV-1 LTNP-EC.