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. 2010 May 26;5(5):e10827. doi: 10.1371/journal.pone.0010827

Table 1. Type-I error rates of various imputation-based association methods for the causal SNP under the significant level of 5%.

Quantitative Trait Qualitative Trait
Low-LD Medium-LD High-LD Low-LD Medium-LD High-LD
Genotyped-1 SNP/6kb 5.0 5.2 5.1 4.9 5.1 4.3
Ideal 5.1 5.0 5.0 5.0 5.1 5.1
SNPTEST 5.0 5.0 4.8 5.0 5.0 4.8
SNPTEST-BG 5.0 5.0 5.1 5.0 5.1 5.1
MACH2qtl/dat 5.0 5.0 5.0 4.9 4.9 5.0
BIMBAM 5.0 4.8 5.0 5.0 4.8 5.0
Beagle - - - 4.9 5.1 4.9
Plink - - - 4.4 4.3 4.4
ProbABEL 5.1 5.1 5.0 5.1 5.2 5.1
SNPMStat - - - 7.0 6.0 4.7