Table 1. Type-I error rates of various imputation-based association methods for the causal SNP under the significant level of 5%.
Quantitative Trait | Qualitative Trait | |||||
Low-LD | Medium-LD | High-LD | Low-LD | Medium-LD | High-LD | |
Genotyped-1 SNP/6kb | 5.0 | 5.2 | 5.1 | 4.9 | 5.1 | 4.3 |
Ideal | 5.1 | 5.0 | 5.0 | 5.0 | 5.1 | 5.1 |
SNPTEST | 5.0 | 5.0 | 4.8 | 5.0 | 5.0 | 4.8 |
SNPTEST-BG | 5.0 | 5.0 | 5.1 | 5.0 | 5.1 | 5.1 |
MACH2qtl/dat | 5.0 | 5.0 | 5.0 | 4.9 | 4.9 | 5.0 |
BIMBAM | 5.0 | 4.8 | 5.0 | 5.0 | 4.8 | 5.0 |
Beagle | - | - | - | 4.9 | 5.1 | 4.9 |
Plink | - | - | - | 4.4 | 4.3 | 4.4 |
ProbABEL | 5.1 | 5.1 | 5.0 | 5.1 | 5.2 | 5.1 |
SNPMStat | - | - | - | 7.0 | 6.0 | 4.7 |