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. 2010 May 26;5(5):e10849. doi: 10.1371/journal.pone.0010849

Figure 1. Compound SmoA1, Pten heterozygotic mice exhibit an increased incidence of medulloblastoma and reduced survival.

Figure 1

SmoA1 +/+ mice were crossed with Pten +/− mice and followed for symptoms. (A) Observed tumor incidence in Pten deficient versus control mice over the course of 1 year. (B) Kaplan-Meier survival analysis of SmoA1 +; Pten +/− (n = 43) and SmoA1 +; Pten (LoxP/-); Nestin-cre + (n = 8) mice, compared to SmoA1 +; Pten +/+ (n = 127) and SmoA1 +; Pten (LoxP/-); Nestin-cre - (n = 7) (p<0.0001, Log-rank) controls. (C) Mice with global Pten deficiency as well as those with conditional, partial knock-out of Pten developed symptoms earlier than controls (p<0.000001 and <0.005, respectively).