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. 2010 May 26;5(5):e10851. doi: 10.1371/journal.pone.0010851

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Aslam, Logie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The plasmid-borne H3-K56 (Q, R) and -S57 (A, E) hht2 point mutations were analyzed for dominant negative effects in YN1038, a strain harboring wild type chromosomal copies of the HHT2 and HHT1 yeast histone H3 genes. Neither growth rates measured at 30°C (A) and nor clone sizes determined on plates containing methyl methanesulfonate, hydroxyurea or formamide (B) revealed any dominant effects of the mutant histone H3 genes when wild type yeast histone H3 was present.