Table 1. Saccharomyces cerevisiae strains used in this study.

Name	Genotype	Reference short hand
YN 1037	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; Euroscarf BY4741	Wild type, ura3
YN 1375	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4, [pMR366-HHT2-URA3] −− hht1Δ ; hht2Δ−−	[3] (WT-URA3)
YN 1392	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56A-HIS3] −− hht1Δ ; hht2Δ−−	[3]
		AS
YN 1393	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56R-HIS3] −− hht1Δ ; hht2Δ−−	[3]
		RS
YN 2168	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_S57A-HIS3] −− hht1Δ ; hht2Δ−−	This work
		KA
YN 2170	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_S57E-HIS3] −− hht1Δ ; hht2Δ−−	This work
		KE
YN 2172	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56R, S57A-HIS3] −− hht1Δ ; hht2Δ−−	This work
		RA
YN 2174	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56R, S57E-HIS3] −− hht1Δ ; hht2Δ−−	This work
		RE
YN 2176	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56Q-HIS3] −− hht1Δ ; hht2Δ−−	This work
		QS
YN 2178	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56Q, S57A-HIS3] −− hht1Δ ; hht2Δ−−	This work
		QA
YN 2180	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56Q, S57E-HIS3] −− hht1Δ ; hht2Δ−−	This work
		QE
YN 2182	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56A, S57A-HIS3] −− hht1Δ ; hht2Δ−−	This work
		AA
YN 2184	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2_K56A, S57E-HIS3] −− hht1Δ ; hht2Δ−−	This work
		AE
YN 2186	MATa; his3Δ1; leu2Δ0; LYS2; met15Δ0; ura3Δ0; YBR010w::kanMX4, YNL031c::kanMX4; [pHHT2-HIS3] −− hht1Δ ; hht2Δ−−	This work
		KS (WT-HIS)