Figure 4. Grp94 deficiency results in embryonic lethality.

(A) Summary of genotypes of embryos at different developmental stages and postnatal progenies from interbred Grp94+/− mice. ND, could not be determined by nested PCR. NA, not applicable. (*) denotes deformed embryos. (B) Morphologies of Grp94+/+, +/−, and −/− embryos at E7.5 and E8.5. Embryos were genotyped through PCR. Scale bars represent 200 µm (upper panel), 300 µm (lower panel).