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. 2010 Jul 1;13(1):39–75. doi: 10.1089/ars.2009.2733

FIG. 6.

FIG. 6.

Structures of cholesteryl ester hydroperoxides responsible for OxLDL–TLR-4 interaction [from (93)]. Cholesteryl ester hydroperoxides have been identified as the biological components of MM-LDL responsible for its interaction with TLR-4 receptors by comparing the lipid profiles of MM-LDL with unmodified LDL and then testing the biological activities of the different components. The figure shows the structure of cholesteryl arachidonate, one of the most common cholesteryl esters found in LDL and the fatty acid portion of cholesteryl arachidonate hydroperoxide (15-HpETE) (R stands for cholesterol) that is responsible for the biological activity of MM-LDL. Similar observations were made for cholesteryl linoleate, another common cholesteryl ester of LDL.