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. Author manuscript; available in PMC: 2010 May 26.
Published in final edited form as: Science. 2002 May 30;297(5579):211–218. doi: 10.1126/science.1071795

Fig. 3.

Fig. 3

NMDAR function is absent only in the C/A-CA3 pathway of CA3-NR1 KO mice. (A) Synaptic responses were evoked and NMDA currents pharmacologically isolated. Details in the Materials and Methods section (17). (Left) Representative data from a control (fNR1) dentate gyrus granule cell (DG) showing a medial perforant path evoked NMDA current (isolated with DNQX and blocked by APV ). (Middle) C/A-evoked NMDA current. (Right) In a CA1 pyramidal cell, SC stimulation-elicited NR-mediated excitatory postsynaptic current. (B) Summary data for NMDA currents in fNR1 and mutant animals (***P < 0.0001).