Table 2.
Changes in weight, GLP-1, PYY, ghrelin, leptin, and amylin after equivalent weight loss (T1) by GBP or GBa
| GBP (n=11) | GB (n=9) | |||||
|---|---|---|---|---|---|---|
| Baseline | Post-weight loss (T1) | Δ | Baseline | Post-weight loss (T1) | Δ | |
| Weight (kg) | 118.3±18.9 | 105.1± 18.4* | -13.3±6.4 | 122.9±20.6 | 111.7±20.7* | -11.3±2.5 |
| BMI (kg/m2) | 45.1±7.8 | 40.1± 6.8* | -5.0±2.2 | 45.7±7.5 | 41.4± 7.3* | -4.2±1.1 |
| Fasting GLP-1T (pmol/L) | 6.8±4.3 | 7.0±3.3 | 0.2±4.2 | 4.9±1.9 | 4.2±1.1§ | -0.6±2.3 |
| GLP-1T Peak (pmol/L) | 15.5±5.9 | 102.3 ±56.1* | 86.8±57.1 | 11.9±5.4 | 17.5 ±18.7§ | 5.6±19.7§ |
| GLP-1T AUC (pmol/L/min) | 7.2±3.0 | 29.0±9.9* | 21.8±9.7 | 4.8±1.2§ | 6.3±4.7§ | 1.5±5.1§ |
| Fasting PYY (pmol/L) | 60.7 ±21.2 | 48.2 ±31.2 | -12.6 ±23.8 | 46.0±25.6 | 46.8 ±11.4 | 0.9±17.0 |
| Peak PYY (pmol/L) | 74.3 ±26.0 | 124.9 ±50.4* | 50.6 ±40.5 | 52.3 ±24.9 | 59.7 ±19.4§ | 7.4 ±21.5§ |
| PYY AUC (pmol/L/min) | 50.5±27.3 | 84.4±32.6* | 33.9±28.7 | 35.7±21.4 | 41.2±13.1§ | 5.5±17.2§ |
| Fasting Ghrelin (pmol/L) | 148.2±36.8 | 135.3±64.3 | -12.9±46.5 | 120.3±32.6 | 136.7±56.3 | 16.3±36.9 |
| Ghrelin Nadir (pmol/L) | 126.1±38.8 | 105.5±45.2 | -20.7±29.5 | 93.7±33.2 | 99.8±49.1 | 6.1±27.8 |
| Ghrelin AUC (pmol/L/min) | 139.3±40.4 | 123.6±49.9 | -15.8 ±32.2 | 111.9±30.2 | 120.9±43.0 | 9.1±28.6 |
| Fasting Leptin (ng/mL) | 34.1±9.7 | 18.3 ±7.9* | -15.7 ±6.3 | 30.4±9.1 | 22.3± 6.6 | -8.1 ±11.7 |
| Fasting Amylin (pmol/L) | 14.5±9.5 | 6.4± 6.3* | -8.1±6.4 | 20.6±25.8 | 26.7± 35.2 | 6.1±14.3§ |
| Amylin AUC (pmol/L/min) | 19.9±9.3 | 9.5±5.2* | -10.4±9.7 | 23.6±22.9 | 27.0± 27.8 | 2.5±12.0§ |
a
Asterisk (*) indicates significantly different from baseline (p<0.05, GLM with repeated measures). Section symbol (§) indicates significantly different from GBP (p<0.05, unpaired t-test)