Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 May 26;2010:340849. doi: 10.1155/2010/340849

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2010 Anibh M. Das et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

llustration of biochemical interactions: the carnitine shuttle, fatty acid oxidation, and glycolysis. The mitochondrial membrane is not permeable to long-chain fatty acids. The carnitine shuttle has to be used to transfer long-chain fatty acids to the mitochondrial matrix space. Once in the mitochondrial matrix space, long-chain acylcarnitines are converted back to long-chain acyl-coenzyme A derivatives and free carnitine via CPT2. Free carnitine is released and the acyl-coenzyme A derivatives will enter the beta-oxidation pathway. CPT1: Carnitine-Palmitoyltransferase 1; CPT2: Carnitine-Palmitoyltransferase 2; CAT: Carnitine-/Acylcarnitine-Transferase; LC: Long-chain; TCA: Tricarboxylic acid cycle; PC: Pyruvate Carcoxylase; PDH: Pyruvate Dehydrogenase.