Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: JALA Charlottesv Va. 2010 Jun 1;15(3):198–209. doi: 10.1016/j.jala.2010.01.008

Figure 4.

Figure 4

Integrated PCR microdevices. (A) Continuous-flow PCR driven by the magnetic force. PCR reaction mixture, pushed by a ferrofluid plug, flows continuously through three temperature zones in the circular channel. (B) PCR array device layout for DNA methylation analysis. Nine functional units are arranged in a circular pattern. A total of 108 reactions can be done with nine sample injections, which significantly improves the throughput. (C) Functional unit layout. The sample inlet is 0.64-mm diameter and reaction chambers at the periphery are 4-mm diameter. Primers specific for tumor suppressor promoters are deposited onto the bottom surface of designated reaction chambers by pipetting. Adapted and reproduced from Refs. 116 and 118, with permission from Springer and RSC.