Fig. 1.

Topical application of 11,14,17-eicosatrienoic acid (ETA) inhibits UV-induced skin thickening and inflammatory cell infiltration in hairless mouse skin in vivo. Female HR-1 hairless mice were topically treated with vehicle (ethanol:polyethylene glycol=30:70) only, 0.1% ETA or 1% ETA once a day for 3 successive days after one time irradiation of UV (200 mJ/cm²) on dorsal skins. Skin biopsy was carried out on the fourth day (72 hr after UV irradiation). (A) Serial sections were mounted onto silane-coated slides and stained with hematoxylin and eosin (H&E) (magnification ×200). (B, C) Epidermal and dermal thicknesses were measured. Values are mean±SEM (n=8).

^*P<0.001 vs. control (CON) vehicle group; ^†P<0.05; ^‡P<0.01 vs. UV-irradiated (UV) vehicle group.