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Activation of ER stress-induced cell death pathway in AD. Western blot analysis of caspase-12, caspase-4, caspase-3, CHOP, and actin in the temporal cortex of control (CTRL) and AD brain (A). Levels of cleaved caspase-12 (B), cleaved caspase-4 (C), cleaved caspase-3 (D), and CHOP (E) were measured and normalized to the level of relevant actin (n = 4 for control and n = 8 for AD).
