Table 1.

Summary of galantamine and donepezil pharmacokinetic data

	Donepezil		Galantamine
	Syringe	Gavage	Syringe	Gavage
Maximal concentration (µM)	0.032 ± 0.004a	0.018 ± 0.020	0.196 ± 0.030	0.414 ± 0.160
Tmax (h; median [range])#	0.500 (0.5–0.5)	1.0 (0.5-2.0)	0.3 (0.1-0.3)	0.3 (0.3-0.5)
AUC(0-t) (µM • h)	0.104 ± 0.020	0.074 ± 0.005	0.282 ± 0.006	0.942 ± 0.405
AUCt/Dose (min • kg / L)	5.070 ± 0.540	3.900 ± 0.370	9.924 ± 0.141	31.283 ± 13.540

AUC, area under the time–concentration curve; t, time of the last measured blood sample

Data are expressed as mean ± SEM (n = 3).

^aSignificantly (P < 0.05) different from value for gavage-dosed donepezil.