Table 1.
Demographic and clinical characteristics
| Characteristics | Non-PGB (N = 155)a | PGB monotherapy (N = 473)a | PGB add-on (N = 676)a | P |
|---|---|---|---|---|
| Sex (female), n (%) | 90 (57.8) | 262 (55.3) | 377 (55.8) | 0.879 |
| Age (years), mean (SD) | 56.3 (13.2) | 56.0 (12.7) | 57.2 (12.1) | 0.230 |
| Body mass index (kg/m2) | 27.9 (4.2) | 27.3 (3.8) | 27.5 (3.8) | 0.204 |
| Marital status (married or with couple), n (%) | 120 (77.2%) | 342 (72.3%) | 498 (73.6%) | 0.525 |
| Labor status, n (%) | 0.149 | |||
| Active | 43 (27.9) | 111 (23.3) | 178 (26.3) | |
| Housewife | 26 (16.9) | 70 (14.7) | 114 (16.8) | |
| Sick leave | 21 (13.6) | 44 (9.1) | 98 (14.5) | |
| Unemployed | 9 (5.8) | 18 (3.7) | 26 (3.7) | |
| Retired | 46 (29.9) | 199 (42.1) | 231 (34.1) | |
| Unknown | 9 (5.8) | 33 (7.0) | 30 (4.5) | |
| Duration (years), mean (SD) | 2.1 (3.7) | 2.1 (4.1) | 1.9 (3.4) | 0.117 |
| No. previous treatments, mean (SD) | 2.8 (1.7) | 2.2 (1.3) | 2.7 (1.4) | <0.001 |
| Previous treatmentsb, n (%) | ||||
| NSAID | 104 (67.1) | 294 (62.2) | 460 (68.1) | 0.039 |
| Paracetamol | 75 (48.4) | 207 (43.7) | 317 (46.9) | 0.442 |
| Metamizol | 41 (26.4) | 96 (20.2) | 134 (19.8) | 0.174 |
| Opioids | 63 (40.6) | 136 (28.8) | 219 (32.4) | 0.022 |
| Antiepileptic drug | 16 (10.1) | 48 (10.2) | 49 (7.3) | 0.173 |
| Tricyclic antidepressants | 14 (8.8) | 24 (5.1) | 59 (8.8) | 0.049 |
| Benzodiazepines | 21 (13.5) | 78 (16.5) | 137 (20.2) | 0.077 |
| Vitamins (B6,B12) | 17 (11.0) | 25 (5.3) | 88 (13.1) | <0.001 |
| Othersc | 10 (6.4) | 19 (4.0) | 78 (11.5) | <0.001 |
NSAID Nonsteroidal antiinflammatory drug, SD standard deviation, AED antiepileptic drug, NPP neuropathic pain, PGB pregabalin;
aTotal number of patients analyzed; some subjects failed to report the data relating to certain variables
bThe patients could have received more than one previous treatment
cIncludes lidocaine, corticoids