Table 2.
Baseline visit patient-reported health outcomes
| Health outcome | Non-PGB (N = 155)a | PGB monotherapy (N = 473)a | PGB add-on (N = 676)a | P |
|---|---|---|---|---|
| SF-MPQ, mean (SD) | ||||
| Sensory | 15.5 (5.8) | 15.1 (6.0) | 16.0 (6.0) | 0.045 |
| Affective | 4.8 (3.3) | 4.4 (3.2) | 5.0 (3.2) | 0.012 |
| Total | 20.3 (8.4) | 19.5 (8.4) | 21.0 (8.5) | 0.016 |
| PPI (0–5) | 2.7 (0.8) | 2.7 (0.8) | 2.8 (0.8) | 0.014 |
| VAS (0–100) | 71.4 (15.3) | 70.4 (14.6) | 72.7 (15.3) | 0.032 |
| MOS-sleep, mean (SD) | ||||
| Summary index (0–100) | 47.6 (16.9) | 46.2 (17.2) | 48.4 (17.2) | 0.096 |
| Sleep disturbance (0–100) | 50.6 (20.1) | 48.5 (19.5) | 51.96 (19.6) | 0.015 |
| Snoring (0–100) | 39.3 (30.6) | 37.3 (28.6) | 37.4 (28.6) | 0.754 |
| Shortness of breath (0–100) | 30.1 (25.4) | 29.5 (26.6) | 31.3 (26.0) | 0.539 |
| Sleep quantity, hours | 5.8 (1.5) | 5.8 (1.4) | 5.6 (1.3) | 0.004 |
| Adequacy of sleep (100–0) | 39.1 (23.6) | 40.0 (23.1) | 36.8 (23.2) | 0.067 |
| Daytime somnolence (0–100) | 40.2 (19.4) | 38.1 (19.0) | 37.5 (19.0) | 0.230 |
| HADS, mean (SD) | ||||
| Depression (0–21) | 10.8 (4.5) | 10.0 (4.5) | 10.7 (4.4) | 0.014 |
| Anxiety (0–21) | 10.5 (3.9) | 9.9 (3.9) | 10.6 (3.8) | 0.022 |
| SDI, mean (SD) | ||||
| Disability (0–30)b | 18.9 (6.0) | 18.4 (5.8) | 20.0 (5.4) | <0.001 |
| Perceived stress (0–100) | 6.0 (2.1) | 5.9 (2.1) | 6.3 (1.9) | 0.007 |
| Perceived social support, % (0–100) | 58.1 (22.3) | 56.0 (22.4) | 57.4 (23.6) | 0.503 |
| EQ-5D | ||||
| VAS, mean (SD) (0–100) | 42.3 (17.2) | 42.5 (18.2) | 38.9 (17.5) | 0.002 |
| Mobilityc, n (%) | 53 (34.9) | 134 (28.9) | 181 (27.0) | 0.051 |
| Personal carec, n (%) | 59 (38.8) | 203 (43.8) | 264 (39.5) | 0.156 |
| Daily life activitiesc, n (%) | 21 (13.8) | 51 (11.1) | 47 (7.0) | <0.001 |
| Without pain, n (%) | 5 (3.3) | 11 (2.4) | 8 (1.2) | 0.002 |
| Without anxiety/depression, n (%) | 37 (24.5) | 127 (27.4) | 150 (22.5) | 0.010 |
SD Standard deviation, VAS visual analog scale, HADS Hospital Anxiety Depression Scale, MOS Medical Outcomes Study, PGB pregabalin, PPI present pain intensity, SDI Sheehan Disability Inventory, SF-MPQ Short Form McGill Pain Questionnaire
aTotal number of patients analyzed; some subjects failed to report the data relating to certain variables
bSum of the scores of the three disability items
cPatients responding without problems in the item