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. 2010 Jun 2;98(11):2420–2431. doi: 10.1016/j.bpj.2010.02.033

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Differences in ionic current dynamics responsible for the AP heterogeneity between PF and ventricular (Endo) cells. (A) Effects of substituting current densities and kinetics of I_Ca,L, I_NaL, I_K1, and I_to from the PF into the Endo model. (B) Effects of substituting current densities only. (C) Comparison of changes in the APD (top) and plateau potential (bottom) due to individual changes (I_NaL, I_Ca,L, I_Kr, I_Ks, I_to, or I_K1) in either current densities and kinetics (black bars) or current densities only (gray bars) in the Endo cell model as compared with the PF cell model (open bars). (D) Comparison of changes in the APD and plateau potential due to combined changes (various combinations of I_Ca,L, I_NaL, I_K1, and I_to) in either current densities and kinetics or current densities only in the Endo cell model as compared with the PF model.