Figure 3.

Model of I_to in PF (A) and ventricular (B) cells. Simulation results (lines) and experimental data (symbols) from PF (9,24) and ventricular (27) cells: (i) steady-state activation and inactivation curves, (ii) activation and inactivation time constants, (iii) current traces generated during 500 ms voltage-clamp pulses from the holding potential of −70 mV to 50 mV in steps of 5 mV, and (iv) I/V relationships. (C) Characteristics of the PF and ventricular cell models: (i) half activation and inactivation voltages, and (ii) simulated peak current densities as compared with experimental data (9,27,31).