Figure 4.

Model of I_Kr in PF (A) and ventricular (B) cells. Simulation results (lines) and experimental data (symbols) from PF (9) and ventricular (28,29) cells: (i) steady-state activation and inactivation curves, (ii) activation and inactivation time constants, (iii) current traces generated during 300 ms voltage-clamp pulses from the holding potential of −40 mV to 100 mV in steps of 5 mV, and (iv) I/V relationships. (C) Characteristics of the PF and ventricular cell models: (i) half activation and inactivation voltages, and (ii) simulated peak current densities as compared with experimental data (9,28). Note that the current density in PF and ventricular models was measured for tail and step currents, respectively, as in experiments.