Figure 3.

(Color) (a) The cargo binding time Δt_b (symbols) increases with the numbers N₊ of kinesins and N₋ of dyneins, and is well approximated by Eq. 3 (lines). Motor parameters are as in Table S1. (b and c) Symmetric tug-of-war of four plus and four minus motors with kinesin parameters as in Table S1. (b) The mean-square displacement MSD (points) increases with time t as (ν_St)² (blue dotted line) for small t and as 2D_St (red dashed line) for large t. The values for D_S, ν_S, and the crossover time (vertical line) are given in the text. (c) The average run time t_R (blue squares) and run velocity ν_R (red diamonds) decrease as a function of γ_s with a sharp reduction for γ_s ≃ 10 pNs/μm. For large γ_s, the run velocity decreases ∼1/γ_s as given by Eq. 5.