Table3.

Univariate and Multivariate analysis for odds of cardiac events using eGFR as continuous variable.

	Unadjusted Odds Ratio (95% CI)	P	Adjusted Odds Ratio (95% CI){Model 1}	P	Adjusted Odds Ratio(95%CI) {Model 2}	P
eGFR value^* (CKD-Epi formula	1.3(1.2-1.5)	<0.001	1.2(1.1-1.4)	0.009
eGFR value^* (MDRD formula)	1.3(1.2-1.4)	<0.001	-	-	1.2(1.1-1.5)	0.004
Proteinuria	3.6(1.9-7)	<0.001	2.9(0.9-9)	0.070	2.7(0.8-8.9)	0.101
Diabetes	4.4(2.1-9.3)	0.010	3.6(0.9-15.3)	0.077	5.9(1.1-29.1)	0.037
Hypertension	3.3(1.8-6.2)	0.001	1.3(0.5-3.9)	0.593	1.9(0.6-6.1)	0.253
Obesity	1.1(0.6-2.3)	0.31	-	-	-	-
Previous cardiac event	13.7(5.6-33.6)	<0.001	29.8(6.1-145.7)	<0.001	91.3(11.7-711.7)	<0.001
Family history	1.9(0.8-4.7)	0.149	-	-	-	-
Dyslipidemia	3.6(1.8-7.1)	<0.001	4.1(1.1-14.9)	0.034	2.9(0.8-10.5)	0.108
Statin use	3.6(1.5-8.7)	0.005	-	-	-	-
Any HAART use	1.1(0.6-1.9)	0.857	-	-	-	-
NRTI use	1.2(0.7-2.2)	0.479	-	-	-	-
PI use	1.4(0.9-2.3)	0.197	-	-	-	-
NNRTI use	0.6(0.3-1.3)	0.209	-	-	-	-
Abacavir use	0.6(0.2-1.4)	0.215	-	-	-	-
Didanosine use CD4 Cell Count (cells/mm³)	0.6(0.1-3.1)	0.574	-	-	-	-
>350	1(ref)	-	1(ref)	-	1(ref)	-
201-350	1.5(0.7-3.2)	0.332	0.4(0.1-1.7)	0.227	0.5(0.1-2.1)	0.308
<200	3.4(1.8-6.6)	<0.001	2.3(0.8-7.1)	0.141	4.8(1.3-18.2)	0.019
HIV-1 RNA (copies/ml)
<1000	1(ref)	-	1(ref)	-	1(ref)	-
1001-50,000	0.8(0.4-1.8)	0.639	2(0.5-7.3)	0.293	2.4(0.6-9.5)	0.201
>50,000	2.4(1.2-4.6)	0.011	1.5(0.3-6.5)	0.596	1.7(0.3-8.7)	0.551

Model 1 analyzed eGFR according to the CKD-EPI equation and Model 2 according to the MDRD GFR estimation formula

CI=Confidence Interval; eGFR=estimated glomerular filtration rate, HAART=highly active antiretroviral therapy; NRTI=nucleoside reverse transcriptase inhibitor; PI=protease inhibitor; NNRTI=non-nucleoside reverse transcriptase inhibitor

Odds Ratio for every 10 ml/min/1.73 m² fall in eGFR