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Statistical analyses of each 384-well plate to determine the quality of the HTS assay performed on the Biogen Idec compounds. Z′ factor analysis was performed on each plate and the average Z′ factor value was 0.83 (upper panel). Z factor analysis was performed on each plate and the average Z factor value was 0.67 (lower panel). Three plates had a Z factor below 0.4 and were rejected during data analysis.
