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T1ρoff-weighted brain images obtained in a healthy volunteer at 3T (α = 65°, ω1 = 400 Hz, ΔωRF = 400 Hz). Phase and frequency alternation of the spin-lock pulse compensates for imperfect flip artifacts; however, there is signal loss in regions of Δω0 inhomogeneity. The flip angle α = 65° deviates from the nominal tan−1(ω1/Δω) = 45° flip necessary for an off-resonance spin lock, and was chosen to amplify the image artifacts.
