(A) Histogram showing relative expression of CXCL10, (B) lipocalin 2, and (C) secretory leukocyte peptidase inhibitor (SLPI) messenger RNA (mRNA) in brains of uninfected (control) and infected rats at 6, 16, and 31 days post infection (d.p.i.). Each bar represents the mean ± S.E.M of values obtained from four animals. Differences with uninfected rats are significant: *P < 0.05 (one-way analysis of variance [ANOVA] followed by Newman Keuls post test). Increased protein levels of lipocalin 2 in CSF from infected rats at late stage are shown in (D). Differences with uninfected rats and with infected rats sacrificed at 6 (n = 6), 11 (n = 5), 16 (n = 4), 21 (n = 5), and 26 (n = 4) d.p.i. are significant: **P < 0.01 (one-way analysis of variance [ANOVA]).