Skip to main content
. 2010 Apr 16;171(10):1144–1152. doi: 10.1093/aje/kwq062

Table 4.

Incident Frailty and Mortality Rates by CMV IgG Antibody Concentration, Women's Health and Aging Studies I and II, Baltimore, Maryland, 1992–2002

All Participants CMV IgG Antibody Concentration, IU/mLa
≤1.20 1.21–10.16 10.17–14.55 14.56–18.16 18.17–150
Incident frailty (3 years)
    No. at risk 482 73 117 101 93 98
    No. of events 80 7 23 14 13 23
    Incidence per 1,000 person-years 60.1 29.6 69.1 52.0 51.9 91.8
    95% CI 48.3, 75.6 14.3, 71.9 46.4, 107.1 30.3, 97.3 30.8, 94.6 62.0, 141.5
    Unadjusted hazard ratio 1.0 2.33 1.82 1.72 3.46
    95% CI 0.98, 5.56 0.70, 4.70 0.67, 4.43 1.45, 8.27
    Adjusted hazard ratio*,b 1.0 2.00 1.44 1.27 2.26
    95% CI 0.79, 5.07 0.53, 3.95 0.46, 3.51 0.89, 5.75
All-cause mortality (5 years)
    No. at risk 635 92 141 128 130 144
    No. of events 91 7 18 17 14 35
    Incidence per 1,000 person-years 28.0 14.0 23.7 27.5 19.1 52.8
    95% CI 22.7, 35.0 6.7, 34.2 14.9, 39.5 16.8, 47.9 11.3, 34.7 37.9, 75.4
    Unadjusted hazard ratio 1.0 1.68 1.97 1.36 3.81
    95% CI 0.68, 4.16 0.78, 4.94 0.53, 3.50 1.64, 8.83
    Adjusted hazard ratio**,b 1.0 1.95 1.87 1.29 2.79
    95% CI 0.81, 4.68 0.75, 4.65 0.52, 3.24 1.22, 6.40

Abbreviations: CI, confidence interval; CMV, cytomegalovirus; IgG, immunoglobulin G.

* P = 0.34; **P < 0.05 (P by likelihood ratio test).

a

A baseline CMV IgG antibody concentration of >1.20 IU/mL was considered seropositive, reflecting prior CMV infection.

b

Hazard ratios were derived from Cox proportional hazards models, adjusting for age, race, high school education, coverage by private medical insurance, pack-years of smoking, cardiovascular disease (angina, myocardial infarction, congestive heart failure, peripheral artery disease, or stroke), diabetes mellitus, and plasma interleukin-6 concentration. Comparisons were made with participants whose CMV IgG antibody concentration was ≤1.20 IU/mL.