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Genetic interactions identify functional dependencies of uncharacterized proteins. (A) DM plot of Δhrd3. (Inset) Enlargement of a region of Fig. 3B, showing genetic interactions of the ERAD cluster. (B) Selected genetic interactions of the ER Membrane Complex (EMC). (C) SDS PAGE analysis of immunoprecipitation of Emc3p -FLAG and associated proteins; protein identities were determined by mass spectrometry. *The specificity of the Por1p interaction has not been evaluated.
