Table 4.
Adverse Reactions Observed in All 23 Patients
| Adverse Event | Number of Events | |||
|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Hypersensitivity/Allergic Reaction | 0 | 0 | 1 | 0 |
| Anemia | 2 | 0 | 1 | 0 |
| Leukopenia | 2 | 0 | 0 | 0 |
| Thrombocytopenia | 3 | 0 | 0 | 0 |
| Hypotension | 0 | 1 | 0 | 0 |
| Thromboembolism | 0 | 0 | 0 | 2 |
| Chills | 14 | 0 | 0 | 0 |
| Fatigue | 11 | 8 | 0 | 0 |
| Hyperpigmentation | 5 | 0 | 0 | 0 |
| Rash/Desquamation | 4 | 1 | 0 | 0 |
| Anorexia | 11 | 6 | 0 | 0 |
| Constipation | 6 | 0 | 0 | 0 |
| Diarrhea | 5 | 5 | 4 | 0 |
| Nausea/Vomiting | 12 | 5 | 1 | 0 |
| Stomatitis | 5 | 2 | 0 | 0 |
| Taste Changes | 7 | 0 | 0 | 0 |
| Elevated Aspartate Aminotransferase | 1 | 0 | 0 | 0 |
| Hyperglycemia | 0 | 1 | 1 | 0 |
| Hypokalemia | 0 | 0 | 1 | 0 |
| Dizziness | 5 | 1 | 0 | 0 |
| Neuropathy | 4 | 0 | 0 | 0 |
| Tearing | 7 | 0 | 0 | 0 |
| Dyspnea | 2 | 5 | 0 | 0 |