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. Author manuscript; available in PMC: 2010 Oct 22.
Published in final edited form as: Nature. 2010 Apr 4;464(7292):1149–1154. doi: 10.1038/nature08894

Figure 1. β-cell ablation and regeneration.

Figure 1

a, RIP-DTR mice express DTR on 100% or 50% of β-cells (blue cells in the cartoon: DTR-bearing β-cells). b-c, Measurement of β-cell mass after ablation and regeneration. Ablation of 99.6% of the β-cell mass is followed by a 3-fold increase between 15 and 30 days (from 5.9μg to 18.5μg), and up to 10-44-fold 10 months later. One-way ANOVA (p=0.0009) and Mann-Whitney tests (* p<0.05). d, Representative islets at various moments after DT. Bars: 20μm.