Table 1.
Functional GO terms associated with genes with a promoter enriched in H3.3-EGFP and indicated combinations of repressive histone modifications
| Combination on promoter | % of genes making up GO terms |
|---|---|
| H3.3/H3K27me3 (n = 74) | |
| Regulation of Rab GTPase activity | 21 |
| Regulation of Ras signal transduction | 8.5 |
| Signal transduction | 15 |
| Muscle differentiation and function | 11 |
| Transport | 11 |
| Other | 33.5 |
| H3.3/H3K4me3/H3K27me3 (n = 80) | |
| Regulation of transcription | 41 |
| Development and differentiation | 38 |
| Macromolecule biosynthesis | 8 |
| Regulation of metabolism | 8 |
| Other | 5 |
| H3.3/H3K9me3 (n = 5) | |
| Response to stimulus | 100 |
| H3.3/H3K9me3/H3K27me3 (n = 2) | |
| No GO terms identified | |
| H3.3/H3K4me3/H3K9me3 (n = 12) | |
| RNA metabolic process | 100 |
| H3.3/H3K4me3/H3K9me3/H3K27me3 (n = 15) | |
| Regulation of transcription | 57 |
| Macromolecule biosynthesis | 11 |
| Metabolic/biological process | 26 |
| Other | 6 |