Table 1.

Initial conditions and parameter estimates that correspond to the best fit of the model to the data.

	Patient 416	Patient 444	Patient 448	Patient 491	Units
I0	0.1	0.1	0.1	0.1	I-units
P0	0.4	0.5	0.58	0.5	P-units
D0	1.7	3.59	0.85	0.38	D-units
A0	0.1	0.1	0.1	0.1	A-units
si	0.001-0.005	0.5-6	0.02-4.5	0.1-0.5	I-units day-1
sid	0.002-0.015	0.5-2	0.02-3.8	0.1-0.6	I-units day-1
kid	1	1	1	1	D-units
kip	0.025	0.015	0.01	0.003	P-units-1 day-1
kpi	0.13	0.01	0.006	0.05	P-units C-units-1 day-1
kpp	0.02	0.015	0.02	0.12	day-1
kpd	0.001	0.001	0.001	0.01	P-units D-units-1 day-1
μp	0.06	0.06	0.13	0.33	day-1
kdip	0.025	0.015	0.01	0.003	P-units-1 day-1
kdp	0.27	0.01	0.03	0.015	D-units P-units-1 day-1
μd	0.04	0.015	0.03	0.035	day-1
sa	0.05-0.3	2-7	0.4-10	1-4	A-units day-1
kap	0.022	0.006	0.035	0.001	A-units P-units-1 day-1
kad	0.22	0.06	0.35	0.01	A-units D-units-1 day-1
μa	2.2	2.2	2.2	2.2	day-1
Ainf	0.45	0.45	0.45	0.45	A-units

For each patient, parameter estimates are given along with the initial conditions for the best fits of the P and D model solutions to the serial measurements of uMCP-1 and uP:C, respectively. Detailed information on parameter estimates for s_i, s_id, and s_a is included in Table 2.